E-ISSN 2548-0839
Volume : Issue : Year : 2024


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Journal Citation Reports (Clarivate, 2023)(Dentistry, Oral Surgery & Medicine (Science))
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European Endodontic Journal The Paradigm of the Inflammatory Radicular Cyst: Biological Aspects to be Considered [Eur Endod J]
Eur Endod J. 2023; 8(1): 20-36 | DOI: 10.14744/eej.2022.26918

The Paradigm of the Inflammatory Radicular Cyst: Biological Aspects to be Considered

Nestor Rios Osorio1, Javier Caviedes-Bucheli2, Lorenzo Mosquera-guevara1, Juan Sebastian Adames-martinez1, Daison Gomez-pinto1, Karin Jimenez-jimenez1, Helida Avendano Maz1, Sandra Bornacelly-mendoza1
1Department of Endodontics, Research Department COC- CICO, University Colleges of Colombia UNICOC, Bogota, Colombia
2Department of Endodontics, School of Dentistry, Pontifical Xavierian University, Bogota, Colombia

Inflammatory radicular cysts (IRCs) are chronic lesions that follow the development of periapical granulomas (PGs). IRCs result from multiple inflammatory reactions led initially by several pro-inflammatory interleukins and growth factors that provoke the proliferation of epithelial cells derived from epithelial cell rests of Malassez present in the granulomatous tissue, followed by cyst formation and growth processes. Multiple
theories have been proposed to help explain the molecular process involved in the development of the IRC from a PG. However, although multiple studies have demonstrated the presence of epithelial cells in most PGs, it is still not fully understood why not all PGs turn into IRCs, even though both are stages of the same inflammatory phenomenon and receive the same antigenic stimulus. Histopathological examination is currently the diagnostic gold standard for differentiating IRCs from PGs. Although multiple studies have evaluated the accuracy of non-invasive or minimally invasive methods in assessing the histopathological nature of the AP before the intervention, these studies' results are still controversial. This narrative review addresses the biological insights into the complex molecular mechanisms of IRC formation and its histopathological features. In addition, the relevant inflammatory molecular mediators for IRC development and the accuracy of non-invasive or minimally invasive diagnostic approaches are summarised. (EEJ-2022-03-041)

Keywords: Apical periodontitis, histopathology, odontogenic cysts, periapical diseases, radicular cyst

Nestor Rios Osorio, Javier Caviedes-Bucheli, Lorenzo Mosquera-guevara, Juan Sebastian Adames-martinez, Daison Gomez-pinto, Karin Jimenez-jimenez, Helida Avendano Maz, Sandra Bornacelly-mendoza. The Paradigm of the Inflammatory Radicular Cyst: Biological Aspects to be Considered. Eur Endod J. 2023; 8(1): 20-36

Corresponding Author: Nestor Rios Osorio
Manuscript Language: English
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