E-ISSN 2548-0839
European Endodontic Journal The Influence of Sodium Hypochlorite and Chlorhexidine on Postoperative Pain in Necrotic Teeth: A Systematic Review []
. 2020; 5(3): 177-185 | DOI: 10.14744/eej.2020.94830

The Influence of Sodium Hypochlorite and Chlorhexidine on Postoperative Pain in Necrotic Teeth: A Systematic Review

Estéfano Borgo Sarmento1, Ludmila Guimarães2, Sandro Tavares1, Katherine Azevedo Batistela Rodrigues Thuller1, Livia Antunes3, Leonardo Antunes3, Cinthya Gomes3
1Postgraduate Program, Faculty of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil
2Postgraduate Program, Faculty of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil
3Department of Specific Formation, Faculty of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil

Objective: The purpose of this systematic review was to provide the answer to the question: Can sodium hypochlorite and chlorhexidine influence postoperative pain after the endodontic treatment in necrotic teeth?
Methods: The PROSPERO registration number is CRD42018096433 and was conducted following the PRISMA statements. The MeSH and free terms were used to search for articles published in the electronic databases (PubMed, Web of Science, Scopus, Cochrane Library, and Virtual Health Library), in the gray literature, and by a manual search. The reviewers selected the studies considering predetermined eligibility criteria, performed data extraction, and evaluated the risk of bias. Only clinical trials comparing the effect of sodium hypochlorite and chlorhexidine on postoperative pain in teeth of adult patients with necrotic pulps were included.
Results: Five studies were qualified for the systematic review. Two studies were considered a low risk of bias. The results showed no statistically significant difference regarding postoperative pain in the groups. Only 1 study reported a statistically significant difference in the sixth postoperative hour, and the pain was associated with the sodium hypochlorite group.
Conclusion: There was no influence of auxiliary chemical substance (NaOCl and CHX) on postoperative pain used in endodontic treatment in the teeth with pulp necrosis. However, one study observed a significant difference in the sixth postoperative hour, associated with the sodium hypochlorite group. (EEJ-2020-01-014)

Keywords: Chlorhexidine, dental pulp necrosis, endodontics, postoperative pain, sodium hypochlorite

Estéfano Borgo Sarmento, Ludmila Guimarães, Sandro Tavares, Katherine Azevedo Batistela Rodrigues Thuller, Livia Antunes, Leonardo Antunes, Cinthya Gomes. The Influence of Sodium Hypochlorite and Chlorhexidine on Postoperative Pain in Necrotic Teeth: A Systematic Review. . 2020; 5(3): 177-185

Corresponding Author: Cinthya Gomes
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