Eur Endod J. 2025; 10(1): 27-34 | DOI: 10.14744/eej.2024.87609

Efficacy of Two Different Concentrations of Iodine-potassium Iodide Solution in Endodontic Retreatment: A Randomised Double-blinded Clinical Trial

Meerna Sarkees¹, Hisham Alafif¹, Samar Ali Alsalameh², Hassan Achour^1
1Department of Endodontics, Damascus University, Faculty of Dentistry, Damascus, Syria
²Department of Basic Science, Damascus University, Faculty of Dentistry, Damascus, Syria

Objective: This study aimed to evaluate the antibacterial effectiveness of two concentrations of iodine-potassium iodide (IKI) used as the final irrigating solution during endodontic retreatment.
Methods: Thirty symptom-free root-filled anterior teeth with chronic apical periodontitis (<5*5mm) were included. They were divided into two groups consisting of 15 teeth according to the method of final irrigation. Group 1 were irrigated with 2% IKI, and Group 2 with 5% IKI. The direct bacterial viable count method was performed to determine the number of colony-forming units (CFUs) before and after disinfection. The reduction in bacterial count was assessed, and statistical analysis was performed using Mann–Whitney U tests with a 95% confidence level.
Results: Irrigation with 5% IKI resulted in significantly reduced bacterial counts than 2% IKI irrigation (p<0.05), indicating greater antibacterial effects.
Conclusion: The use of a 5% IKI solution as the final irrigating agent in endodontic retreatment cases with chronic apical periodontitis significantly reduces bacterial counts compared to a 2% IKI solution. The 5% IKI solution therefore exhibited a superior antibacterial effect. Consequently, 5% IKI solution application improves microbiological outcomes and enhances the overall disinfection of the root canal system. (EEJ-2024-08-131)

Keywords: Antibacterial, colonies forming units, endodontic retreatment, iodine-potassium iodide, periapical lesion

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