E-ISSN 2548-0839
Volume : 9 Issue : 3 Year : 2024

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Regenerative Endodontic Procedures in Teeth with Root Resorption: A Systematic Review [Eur Endod J]
Eur Endod J. 2023; 8(3): 170-186 | DOI: 10.14744/eej.2023.77486

Regenerative Endodontic Procedures in Teeth with Root Resorption: A Systematic Review

Ashwini Manish Dadpe1, Dipali Yogesh Shah1, Velmurugan Natanasabapathy2, Nivedhitha Malli Sureshbabu3, Ajit Narayan Hindlekar4, Kajal Modi2
1Department of Conservative Dentistry and Endodontics, Sinhgad Dental College & Hospital, Pune, India
2Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, Chennai, India
3Department of Conservative Dentistry and Endodontics, Saveetha Dental College & Hospitals, Chennai, India
4Department of Conservative Dentistry and Endodontics, Dr. D. Y. Patil Dental College & Hospital, Pune, India

The purpose of this systematic review was to critically evaluate the available clinical literature on the use of regenerative endodontic therapy (RET) for the treatment of root resorption. All case reports, case series and clinical studies documenting the management of root resorption in mature or immature permanent teeth using RET were included. Review articles, animal studies, and RET in teeth showing developmental anomalies were excluded. A literature search was conducted in electronic databases MEDLINE, Scopus, Cochrane, and Google Scholar from 2001 to January 2022. The JBI Critical Appraisal Checklist Quality was used to appraise the included case reports and case series. The Methodological item for non-randomised studies (MINORS) tool was used to appraise the clinical study critically. After applying the inclusion and exclusion criteria, the search resulted in 14 studies (12 case reports, 1 case series, and 1 clinical study) accounting for root resorption in 34 teeth from 29 patients treated with RET. Despite the wide variation in RET protocols, the arrest of root resorption and resolution of symptoms was seen in all teeth except one (failure after 27 months). The clinical study’s cone beam computed tomography (CBCT) imaging evalu- ation documented a significant volumetric decrease in resorptive and periapical lesions after RET. The clinical study was deemed as good quality using the MINORS scale. The JBI critical appraisal tool showed that the case series was of poor quality; 11 of the case reports were of good quality, while 1 case report was of fair quality. This systematic review revealed a low-to-moderate level of evidence for the use of RET in resorption cases. However, further well-designed, long-term clinical studies are required to recommend it as an alternative treatment option for root resorption management. Funding: None. The systematic review was registered in PROSPERO (CRD42021274569). (EEJ-2022-11-136)

Keywords: Case reports, regenerative endodontics, reparative endodontics, root resorption, systematic review

Ashwini Manish Dadpe, Dipali Yogesh Shah, Velmurugan Natanasabapathy, Nivedhitha Malli Sureshbabu, Ajit Narayan Hindlekar, Kajal Modi. Regenerative Endodontic Procedures in Teeth with Root Resorption: A Systematic Review. Eur Endod J. 2023; 8(3): 170-186

Corresponding Author: Ashwini Manish Dadpe
Manuscript Language: English
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