E-ISSN 2548-0839
Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin versus MTA for Direct pulp capping in patients with symptomatic reversible pulpitis- A randomized controlled trial [Eur Endod J]
Eur Endod J. Ahead of Print: EEJ-04834 | DOI: 10.14744/eej.2021.04834

Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin versus MTA for Direct pulp capping in patients with symptomatic reversible pulpitis- A randomized controlled trial

Shekar Shobana1, Mahendran Kavitha2, Narasimhan Srinivasan3
1Department of Conservative Dentistry and Endodontics, Tagore Dental College and Hospital, Rathinamangalam, Tamil Nadu, India
2Tamil Nadu Government Dental College, No 1, Tamil Nadu, India
3Hamad Dental Center, Hamad Medical Corporation, Doha, Qatar

Objectives: The aim of this study was to assess the effectiveness of Platelet Rich Plasma (PRP), Platelet Rich Fibrin (PRF) and Mineral Trioxide Aggregate (MTA) as direct pulp capping materials in patients with symptomatic reversible pulpitis using cone beam computed tomographic (CBCT) assessment. Methods: This parallel, triple blinded, randomized trial was done on 30 carious posterior teeth with reversible pulpitis which were chosen based on stringent inclusion and exclusion criteria. The samples were allocated based on SNOSE method into three groups: MTA, PRP and PRF for direct pulp capping. The treated teeth were restored with GIC liner and Light cure composite resin. Patients were followed up for a period of 12 months. Statistical analyses were performed with statistical software SPSS version 25. Data were analysed for normality using Shapiro Wilk’s test. Dentin bridge volume analysis across the groups were done using Kruskal Wallis test with the significance level at p= 0.05. As the test revealed a significant difference, post hoc analysis was done with Dunn test. Results: CBCT analysis revealed that the volume of dentin bridge formed by PRP and PRF was significantly higher than the volume of dentin bridge formed by MTA (p<0.001; CI: 90%). There was no significant difference in the efficacy between the three direct pulp capping agents based on clinical assessment. A total of 27 teeth (90 % of the cases) showed positive response to pulp sensibility testing and evidence of dentin bridge formation radiographically at 12 months. No adverse events were encountered. Conclusion: Platelet concentrates could be the future of vital pulp therapy for adult permanent teeth with reversible pulpitis. (EEJ-2021-05-078)

Keywords: Cone beam computed tomography; Direct pulp capping; Mineral trioxide aggregate; Platelet rich fibrin; Platelet rich plasma; Reversible pulpitis



Corresponding Author: Shekar Shobana
Manuscript Language: English
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